Courteney Cox isn't done running from masked serial killers.

The 45-year-old "Cougar Town" and "Friends" star says she's excited about returning to the horror genre in "Scream 4," the upcoming slasher sequel being written by Kevin Williamson, who wrote the first two films in the popular horror trilogy. Cox met her husband, 38-year-old actor David Arquette, on the set of the first "Scream" film in 1996.

"There are really only a few of us that survived," says Cox.

Cox and Arquette will reprise their roles as overzealous reporter Gale Weathers and bumbling sheriff Dwight "Dewey" Riley in the fourth installment, along with 36-year-old actress Neve Campbell, who starred as the series' heroine, Sidney Prescott. Cox shrugged off rumors that Weathers and Dewey would be killed off at the beginning of the film.

"They're probably back living in Woodsboro," Cox said referring to the small California town that was the setting of the first film. "I think that he's probably still deputy, and I've had a lot of kids. I don't know. I'm probably miserable, and then I'm sure a lot of murdering will happen."